2021

February: 

• Stephen and I are very happy to have contributed to this interesting study "Long-term maturation of human cortical organoids matches key early postnatal transitions", a collaboration with Dr. Dan Geschwind and other groups.

January: ​

• Our paper "Allele-specific alternative splicing and its functional genetic variants in human tissues" is published at Genome Research. Congratulations to Kofi, Esther, Jae, Yiwei, Christina, Boon and Ei-Wen!
• We welcome rotation students Patricia Mendez and Mark Xiang to our lab!

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2020

December: 

• We received an NIH R01 grant to support our work in "Systematic approaches to deciphering regulation and function of RNA editing in brain".

November: 

• Kiku and I are glad to have contributed to this interesting study by Dr. Yong Kim's group: "Molecular consequences of fetal alcohol exposure on amniotic exosomal miRNAs with functional implications for stem cell potency and differentiation".
• Tadeo awarded the UCLA CARE fellowship.

October: 

• Our paper “RNA editing in cancer impacts mRNA abundance in immune response pathways” is published in Genome Biology. Congratulations to Tracey, Ting, Jae, Giovanni and all coauthors!  
• Our paper "Extracellular microRNA 3’ end modification across diverse body fluids" is published in Epigenetics.  Congratulations to Kiku and Jae!

September: 

• We welcome rotation students to our lab, Auriana Arabpour, Elaine Huang, and Nguyen Phi! Looking forward to an exciting quarter (despite virtually)!

August: 

• We welcome undergraduate student, Tadeo Spencer, to our lab!
• Congratulations to Ting Fu for receiving the Hyde Fellowship!
• Congratulations to Jonatan Hervoso for receiving funding as a Diversity Scholar!
• UCLA's 2020 Bruins-in-Genomics (BIG) Summer program wraps up this month. We are grateful to the program directors and the administrative team for stellar organizations of the first-ever remote BIG Summer! What a great achievement for the student mentees and mentors!!!  We say farewell to our trainees Bridget and Tori, and we congratulate them on receiving the Research Excellence Award.  We also congratulate Kofi for serving as a fantastic mentor to Bridget and Tori and receiving the Outstanding Mentor Award!
• We welcome Dr. Zhiheng Liu to our lab!
• ​AUG 1, happy RNA day!

July: 

• Introducing the ENCODE 3 landing page at Nature.   Enjoy reading the consortium paper and the companions!
• We are delighted to have been part of the ENCODE 3 consortium (and the current ENCODE 4 consortium).  Congratulations to Giovanni, Ei-Wen and Esther for your contributions as ENCODE3 consortium members. We are grateful for the inclusion of two of our papers on the Nature landing page!

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June: 

• Check out  this interesting study by Dr. Yibin Wang's group: "p38 mitogen-activated protein kinase regulates chamber specific perinatal growth in heart" published at the Journal of Clinical Investigation. We are glad to have contributed to this work.
• UCLA's 2020 Bruins-in-Genomics (BIG) Summer program kicks off this month!  We welcome two BIG Summer students to our lab: Tori Concepcion and Bridget Phillips!
• Congratulations to Carlos Gonzalez-Figueroa for receiving the Cellular and Molecular Biology Training Grant!
• We welcome Jonatan Hervoso to our lab!

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May: 

• While sheltering at home, our lab members have been hard-at-work! Our manuscript "Allele-specific alternative splicing in human tissues" is now on BioRxiv. Congratulations Kofi, Jae, Esther, Yiwei, Christina, Boon, Ei-Wen!

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March: 

• We welcome Carlos Gonzalez-Figueroa to our lab!
• Our manuscript "Extracellular microRNA 3' end modification across diverse body fluids" is now on BioRxiv. Congratulations Kiku and Jae!
• Our manuscript "Differential RNA editing between epithelial and mesenchymal tumors impacts mRNA abundance in immune response pathways" is now on BioRxiv. This work was spearheaded by two graduate students, Tracey Chan and Ting Fu, and in collaboration with Dr. Chonghui Cheng at Baylor College of Medicine!

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February: 

• Kiku and I are glad to have contributed to this interesting study by Dr. Feng Guo's lab: "Fe(III) heme sets an activation threshold for processing distinct groups of pri-miRNAs in mammalian cells".

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January: 

• Our paper describing the new statistical methods, named REDITs, to analyze differential RNA editing is published at Bioinformatics!  Congratulations, Stephen!
• The REDITs package is available for download at our lab's GitHub page.
• We welcome rotation students Carlos Gonzalez-Figueroa and Jonatan Hervoso to our lab!

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2019

November:

• Congratulations to Kofi for successfully advancing to PhD candidacy. Great job, Kofi!

September:

• We received an NIH R56 grant to support our work on Alzheimer's disease.
• Our paper "mountainClimber identifies alternative transcription start and polyadenylation sites in RNA-seq" is online at Cell Systems. 

August:

• Stephen delivered a fantastic dissertation defense seminar! Congratulations, Dr. Tran!
• We received a Program Vision Leader Award to support our research in cancer. We thank the JCCC of UCLA for this award.
• Our research is featured in the UCLA College Magazine - "The Future of Aging, Disease, Brain Health, Biodiversity & more" ​https://www.college.ucla.edu/the-future-of/

July: 

• Our manuscript "mountainClimber identifies alternative transcription start and polyadenylation sites in RNA-seq" is accepted to Cell Systems. Congratulations, Ashley!  
• Check out mountainClimber at our gitHub page: https://github.com/gxiaolab/mountainClimber
• We welcome BIG Summer student Peter Nekrasov to our lab!

June: 

• Mudra is awarded the Biomedical Big Data Training grant. Congratulations, Mudra!

May: 

• Congratulations to Mudra for winning the Best Poster Award at the 2019 GATP-BWF-BBD Joint Symposium!
• Congratulations to Ei-Wen for delivering a fantastic lightning talk at the ITCR meeting!

April: 

• Our collaborative paper with Dr. Tao Jiang's group "DeepPASTA: Deep neural network based polyadenylation site analysis" is published at Bioinformatics!
• Check out the publication by The Extracellular RNA Communication Consortium: Establishing foundational knowledge and technologies for extracellular RNA research. We are pleased to contribute through Dr. David Wong's group.
• Congratulations to Ei-Wen for winning a travel award to the ITCR annual meeting!​

March: 

• Our paper "Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA" is published at Nature Communications.​ Congratulations to Ei-Wen, Jae, Esther, Boon, Yiwei, Ting and Giovanni!

January: 

• Check out the various coverages on our Autism study, e.g.: UCLA News Room, Ars Technica, Spectrum
• Our paper “Regulation of RNA editing by RNA-binding proteins in human cells” is published at Communications Biology. Congratulations to Giovanni, Stephen, Hyun-Ik, Jae, Ei-Wen and Anneke!
• Congratulations to Kofi for winning the Poster Award at the 2019 ENCODE Consoritum meeting!

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2018

December:

• Our paper “Widespread RNA editing dysregulation in brains from autistic individuals.” is published at Nature Neuroscience. Congratulations Stephen, Hyun-Ik, Jae, Adel, Esther!
• Congratulations to Christina for successfully advancing to PhD candidacy. Great job, Christina!
• Congratulations to Ting for successfully advancing to PhD candidacy. Great job, Ting!

November:

• Our collaborative paper with Dr. Kosuri’s lab “A multiplexed assay for exon recognition reveals that an unappreciated fraction of rare genetic variants cause large-effect splicing disruptions” is published at Molecular Cell.  Congratulations, Christina and Esther!
• Congratulations to Mudra for successfully advancing to PhD candidacy. Great job, Mudra!

October:

• Our paper “Widespread RNA editing dysregulation in Autism Spectrum Disorders” is now on BioRxiv. Congratulations to all co-authors!

September:

• Quantitative Biology ‘s Special Issue on RNA Processing and Regulation edited by Dr. Xiao and Dr. Chaolin Zhang is now online.

• Congratulations to Ashley, Ei-Wen, Giovanni, Kofi, and Yi-Wei for presenting their work at the QCBio retreat!

August:

• Our paper analyzing ENCODE eCLIP-Seq data: “Allele-specific binding of RNA-binding proteins reveals functional genetic variants in the RNA” is now on BioRxiv. Check it out!
• Ashley presented a fantastic dissertation defense seminar! Congratulations, Dr. Cass!
• Michele Ramos and Elaine Huang wrapped up their BIG summer research with us, and they won the poster award at BIG summer poster session. Thanks to Kiku for great mentoring!

July:

• Our collaborative paper with Dr. Chonghui Cheng’s group Co-regulation of alternative splicing by hnRNPM and ESRP1 during EMT. is published at RNA. 
• We welcome BIG summer students Michele Ramos and Elaine Huang to our lab!

June:

• Mudra Choudhury is awarded a Biomedical Big Data Training grant! Congratulations, Mudra!
• Esther delivered a fantastic dissertation defense seminar and with that, completed her PhD study! Congratulations, Dr. Hsiao!  

May:

• Congratulations to Giovanni for successfully advancing to PhD candidacy!
• Kiku Koyano is awarded the Eureka Scholarship!  Congratulations, Kiku!
• Our collaborative paper with Dr. Bill Lowry’s group Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence. is published at Stem Cell Reports. Congratulations, Stephen!
• Check out the news coverage on the study “Human tRNA-derived small RNAs modulate host-oral microbial interactions”!
• Our paper “RNA editing in nascent RNA affects pre-mRNA splicing” is online at Genome Research. Congratulations, Esther, Jae, Yun, Andrew, Stephen, Ei-Wen, Giovanni!

April:

• Our collaborative paper with Dr. David Wong’s group “Human tRNA-derived small RNAs modulate host-oral microbial interactions” is published at the Journal of Dental Research. Congratulations, Kiku!
• Our collaborative paper with Dr. David Wong’s group “Characterization of Human Salivary Extracellular RNA by Next-generation Sequencing” is published at Clinical Chemistry. Congratulations, Kiku and Ken!

March:

• Congratulations to Kiku and Tracey for successfully advancing to PhD candidacy!!

February:

• Our collaborative paper with Dr. Tao Jiang’s lab “TAPAS: Tool for Alternative Polyadenylation Site Analysis” is published at Bioinformatics. Available online now! 

 January:

• ​Our collaborative paper with Dr. Stephanie White’s lab “FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch” is published at eLife.  Congratulations, Zach!